A novel withanolide with an unprecedented carbon skeleton from Physalis angulata.

Cytotoxic withanolides from Vietnamese ethno-medicinal plant Physalis angulata

Withanolides are known as the main components of Physalis genus with broad biological activities. Using combination of various chromatographic methods, three withanolides were isolated including physagulin J (1), physagulin K (2), and physagulin N (3). Their chemical structures were determined by analysis of NMR spectra, and as well as comparison with reported literature. Compound 1 showed sign...

Withanolides from Physalis hispida.

Nine new withanolides (1-9), withahisolides A-I, were isolated along with nine known compounds (10-18) from the aerial parts of Physalis hispida. The structures of 1-9 were elucidated through a variety of spectroscopic techniques, while the structures of 1 and 2 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are the first withanolides with nonaromatic six-membered ring D moiet...

The Ethanol Extract of Physalis angulata Linn Inhibits COX-2 Activity in MCF-7 Cell In Vitro

Some studies showed that ceplukan (Physalis angulata Linn) have cytotoxic effects toward HeLa (cervical cancer), KB (Nasopharyngeal), Colo 205 (colon), Calu (Lung) and MCF-7 cells in vitro. This plant has cytotoxic effects toward rat P388 lymphocytic leukemia in vivo. One of the mechanisms of cytotoxicity is the inhibition of Cyclooxygenase-2 (COX-2) pathway. The purpose of this study was to de...

A new withanolide glycoside from physalis peruviana

A new withanolide glycoside, 17beta-hydroxy-14, 20-epoxy-1-oxo-[22R]-3beta-[O-beta-D-glucopyranosyl]-witha-5, 24-dienolide (1), has been isolated from the whole plant of Physalis peruviana. Its identity was determined using a combination of spectroscopic data including 2D NMR techniques and chemical transformations.

Physalis Angulata L . : an Ethanopharmacological Review